Treatment of venous disorders.

Venoruton 300 CAPSULE contains:
300mg of the active substance 0-(b-hydroyethyl)-rutosides, and excip. q.s.

Venoruton Forte TABLET contains:
500mg of the active substance 0-(b-hydroyethyl)-rutosides, and excip. q.s.



What is Venoruton used for?
Dosage:
Drud Interaction
When Venoruton must not be used?
What undesirable side effects can Venoruton have?
Can Venoruton be used during pregnancy or when breast feeding?

What is Venoruton used for?
Venoruton is indicated for oedema and symptoms (painful, tired, heavy, swollen legs with cramps and paraesthesia) associated with chronic venous insufficiency; postphlebitic syndrome, trophic disorders, varicose dermatitis and varicose ulcers. Venoruton can also be used as adjuvant treatment in the sclerotherapy and stripping of varices. Also, it is indicated for symptoms of hemorrhoids (pain, exudation, pruritis and bleeding) and their complications.

Venoruton acts on the capillary wall, increasing its resistance and normalizing its permeability. These effects have been demonstrated in a variety of experimental models and in many patients with chronic venous insufficiency, secondary effects of radio-therapy, and microthrombotic or ischaemic retinal vascular disorders.

Venoruton has also been shown to have an inhibitory effect on erythrocyte aggregation and a protective action on the vascular endothelium. Venoruton is thus indicated for the treatment of chronic venous insufficiency, through its effects in reducing oedema and symptoms such as pain, cramps, trophic disorders, varicose dermatitis and varicose ulcers.

Venoruton alleviates the symptoms habitually associated with hemorrhoids, such as pain, exudation, pruritis and bleeding.

Venoruton attenuates the secondary effects of radiotherapy such as cystitis, enteroproctitis, dysphagia, cutaneous erythema, etc., which frequently cause radiotherapy to be discontinued.

By its beneficial effects on capillary resistance and permeability, Venoruton also checks the development of diabetic retinopathy. In addition, its effects on blood rheology alleviate microthrombosis and other forms of retinal vascular ischaemia.
TOP

Dosage :
Venoruton 300 TABLETS:

Usual dosage
2 to 3 capsules of Venoruton 300 a day with meals. After the disappearance of symptoms, usually in 2 to 4 weeks, it is advisable to continue treatment for some weeks to consolidate the results obtained. The exceptional therapeutic margin of Venoruton makes it possible to increase the dosage, adapting it to each individual case

Maintenance treatment:
The minimum maintenance dose is 600mg per day, i.e. 1 Venoruton 300 capsule twice daily.

Venoruton Forte CAPSULES:

Chronic venous insufficiency: 1 tablet twice a day with meals. After the disappearance of symptoms, usually in 2 to 4 weeks, it is advisable to continue treatment for some weeks to consolidate the results obtained.

side effects of radiotherapy: 1 tablet twice a day with meals, for the entire duration of irradiation and until the disappearance of symptoms.

Retinal vascular disorders: The best results are obtained with doses amounting to 1 to 2 g per day. i.e. 1 or 2 Venoruton fort tablets twice a day with meals.
TOP

Drug Interaction:
No interactions have been reported so far.
TOP

When Venoruton must not be used?
to its active ingredient 0-(b-hydroyethyl)-rutosides, or to other rutosides.
TOP

What undesirable side effects can Venoruton have?
minor side effects have occasionally been reported (skin rashes, mild gastro-intestinal upsets, headaches and flushes). They disappear rapidly after withdrawal of the treatment.
TOP

Can Venoruton be used during pregnancy or when breast feeding?
Although no abnormalities have been observed in teratogenic studies or in humans, it is recommended, in accordance with general clinical practice, not to use O-(b-hydroxyethyl)-rutosides in the first three months of pregnancy.
Traces of 0-(b-hydroyethyl)-rutosides encountered in the fetus and in breast milk (animal experiments) are not considered to be clinically relevant.
TOP

Remarks:
Protect from moisture and store below 30 C.
TOP

Packaging:
Venoruton 300 pack of 20 capsules.
Venoruton Forte pack of 30 tablets.
TOP